Multiplex Technology
A clear answer for complex immunobiological questions
Multiplex Technology is a highly performing platform used for many innovative findings. This technology was initially used to identify most optimal antigens and in a second step for assay development.
InfYnity Biomarkers has combined its expertise in Multiplex technology and epitope mapping by developing serological immunoassays for several infectious diseases such as:
SARS-CoV-2 (Covid), Chagas, HTLV-1 and 2, HIV 1, 2 and subtype O, Syphilis and Onchocerciasis.
Multiplex Assay Design
Multiplex technology is based on a 96-well microplate. Each well contains a range of biomarkers. The illustration represents one well:
- Up to 50 different Antigens printed in precise positions
- Each antigen can be printed in duplicates to give a robust information
- 4 Positive controls (PC) for spatial orientation and technical validation of the assay
Applications
- Screening platform to identify and compare different types of biomarkers (proteins e.g. infectious diseases, allergens, antibodies, polluants e.g. pesticides) and accelerate assay development
- Fine-tune the composition of a mix of antigens to achieve better specificity and sensitivity through the identification of the antigens causing the false-reactivity and their replacement in the mix
- Immunoprofiling (e.g., natural vs vaccine-induced, drug treatments, prognosis)
- Generating cytokine profiles
- Vaccine development
Target Markets
- In vitro Diagnostics:
-Infectiology -Auto-Immunity -Allergy -Oncology -Neurodegenerative Disease -Immunotherapy monitoring -Drug/Vaccine companion
- Chemical diagnostics:
-Toxicology
- Therapeutic:
-Immunotherapy monitoring -Drug/Vaccine companion
Advantages
- Serological signature unique for each patient
- Test in one shot 50 different antigens/antibodies generating highly informative profile in one single well
- Efficient in terms of cost, time & resource consumption
- Visual
- Wide dynamic range
- Test results under the same experimental conditions
Multiplex Immunoassay Kits
Multi-SARS-CoV-2 Kit
Multi-SARS-CoV-2 test is a high resolution in-vitro diagnostic Multiplex ELISA assay (RUO) which enables simultaneous detection of anti-SARS-CoV-2 antibodies to a set of selective and validated antigens.
Multi-Cruzi Kit
The Multi-Cruzi test is a high resolution in-vitro diagnostic Multiplex ELISA assay (RUO) which permits the simultaneous detection and identification of anti-T. cruzi antibodies directed against 15 different T. cruzi antigen specificities.
Multi-HTLV Kit
Multi-HTLV is a novel high-resolution Multiplex ELISA assay (RUO) for the confirmation and discrimination of Human T-cell Lymphotropic Virus type I (HTLV-I) and type II (HTLV-II) infections, by antibodies detection in human serum or plasma.